Duke University v. Biomarin Pharmaceutical Inc.

Issue: (1) Whether a court of appeals can invoke forfeiture to refuse to address an appointments-clause violation in a pending appeal despite an intervening change in law; and (2) whether the U.S. Patent and Trademark Office Director"s delegation of authority to institute inter partes reviews to administrative patent judges acting as principal officers outside the director"s review violates 35 U.S.C. § 314, which vests institution authority solely in the director; and (3) whether establishing a nexus between a patentee"s invention and objective evidence of nonobviousness under Graham v. John Deere Co. requires the patentee to negate every other conceivable reason for a product"s commercial success and industry praise.